Clonazepamum

Clonazepamum may be available in the countries listed below.

Ingredient matches for Clonazepamum

Clonazepam

Clonazepam is reported as an ingredient of Clonazepamum in the following countries:

• Poland

International Drug Name Search

Tracetin

Tracetin may be available in the countries listed below.

Ingredient matches for Tracetin

Bacitracin

Bacitracin is reported as an ingredient of Tracetin in the following countries:

• Indonesia

Neomycin

Neomycin is reported as an ingredient of Tracetin in the following countries:

• Indonesia

International Drug Name Search

Tramake

Tramake may be available in the countries listed below.

Ingredient matches for Tramake

Tramadol

Tramadol hydrochloride (a derivative of Tramadol) is reported as an ingredient of Tramake in the following countries:

• Ireland

International Drug Name Search

Artesol

Artesol may be available in the countries listed below.

Ingredient matches for Artesol

Cilostazol

Cilostazol is reported as an ingredient of Artesol in the following countries:

• Chile

International Drug Name Search

Dermosept

Dermosept may be available in the countries listed below.

Ingredient matches for Dermosept

Chlorhexidine

Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Dermosept in the following countries:

• Bahrain

International Drug Name Search

Palux

Palux may be available in the countries listed below.

Ingredient matches for Palux

Alprostadil

Alprostadil is reported as an ingredient of Palux in the following countries:

• Japan

International Drug Name Search

Anquil

Anquil may be available in the countries listed below.

Ingredient matches for Anquil

Benperidol

Benperidol is reported as an ingredient of Anquil in the following countries:

• Ireland


• United Kingdom

Midazolam

Midazolam is reported as an ingredient of Anquil in the following countries:

• Bangladesh

International Drug Name Search

Pain Will Pass

Pain Will Pass may be available in the countries listed below.

Ingredient matches for Pain Will Pass

Tiaprofenic Acid

Tiaprofenic Acid is reported as an ingredient of Pain Will Pass in the following countries:

• Taiwan

International Drug Name Search

Scanmecob

Scanmecob may be available in the countries listed below.

Ingredient matches for Scanmecob

Mecobalamin

Mecobalamin is reported as an ingredient of Scanmecob in the following countries:

• Indonesia

International Drug Name Search

Zotrilax

Zotrilax may be available in the countries listed below.

Ingredient matches for Zotrilax

Triazolam

Triazolam is reported as an ingredient of Zotrilax in the following countries:

• Italy

International Drug Name Search

Q-Met

Q-Met may be available in the countries listed below.

Ingredient matches for Q-Met

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Q-Met in the following countries:

• India

International Drug Name Search

Cimetidine ratiopharm

Cimetidine ratiopharm may be available in the countries listed below.

Ingredient matches for Cimetidine ratiopharm

Cimetidine

Cimetidine is reported as an ingredient of Cimetidine ratiopharm in the following countries:

• Netherlands

International Drug Name Search

Ascorell

Ascorell may be available in the countries listed below.

Ingredient matches for Ascorell

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Ascorell in the following countries:

• Germany

International Drug Name Search

Dompéridone Winthrop

Dompéridone Winthrop may be available in the countries listed below.

Ingredient matches for Dompéridone Winthrop

Domperidone

Domperidone is reported as an ingredient of Dompéridone Winthrop in the following countries:

• France

International Drug Name Search

Prinzide Mepha

Prinzide Mepha may be available in the countries listed below.

Ingredient matches for Prinzide Mepha

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Prinzide Mepha in the following countries:

• Switzerland

Lisinopril

Lisinopril dihydrate (a derivative of Lisinopril) is reported as an ingredient of Prinzide Mepha in the following countries:

• Switzerland

International Drug Name Search

Etono

Etono may be available in the countries listed below.

Ingredient matches for Etono

Tripelennamine

Tripelennamine hydrochloride (a derivative of Tripelennamine) is reported as an ingredient of Etono in the following countries:

• Finland

International Drug Name Search

Lignocaine Jelly

Lignocaine Jelly may be available in the countries listed below.

Ingredient matches for Lignocaine Jelly

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Lignocaine Jelly in the following countries:

• Germany

International Drug Name Search

Testosterone

In some countries, this medicine may only be approved for veterinary use.

In the US, Testosterone (testosterone systemic) is a member of the drug class androgens and anabolic steroids and is used to treat Breast Cancer - Palliative, Delayed Puberty - Male, Hypogonadism - Male and Postpartum Breast Pain.

US matches:

• Testosterone


• Testosterone Cypionate


• Testosterone Enanthate


• Testosterone Gel


• Testosterone Patch


• Testosterone Solution


• Testosterone buccal system


• Testosterone injection


• Testosterone topical


• Testosterone Buccal


• Testosterone Topical application


• Testosterone Transdermal

UK matches:

• Testosterone Enanthate Ampoules (Cambridge Laboratories)
• Testosterone Enanthate Ampoules (Cambridge Laboratories) (SPC)
• Testosterone Implant 100mg (Organon Laboratories Ltd) (SPC)
• Testosterone Implant 200 mg (SPC)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

G03BA03

CAS registry number (Chemical Abstracts Service)

0000058-22-0

Chemical Formula

C19-H28-O2

Molecular Weight

288

Therapeutic Category

Androgen

Chemical Name

Androst-4-en-3-one, 17-hydroxy-, (17ß)-

Foreign Names

• Testosteronum (Latin)
• Testosteron (German)
• Testostérone (French)
• Testosterona (Spanish)

Generic Names

• Testosterone (OS: DCIT, BAN)
• Testostérone (OS: DCF)
• Mertestate (IS)
• Synandrol F (IS)
• Testandrone (IS)
• Testobase aqueous (IS)
• Testodrin (IS)
• Testosteroid (IS)
• Testryl (IS)
• Virosterone (IS)
• Testosteron (PH: Ph. Eur. 6)
• Testosterone (PH: BP 2010, USP 32, Ph. Eur. 6)
• Testostérone (PH: Ph. Eur. 6)
• Depo-Testadiol (IS)
• Supertest (IS)
• Testosterone cyclopentanepropionate (IS)
• Testosterone Cypionate (PH: USP 32)
• Testosterone Decanoate (PH: BP 2010)
• Testosterone Enanthate (OS: BANM)
• Testosterone Heptanoate (OS: JAN)
• 4-08-00-00979 (IS: Beilstein)
• BRN 3170544 (IS)
• CCRIS 7082 (IS)
• EINECS 206-253-5 (IS)
• NSC-17591 (IS)
• Testostérone héptylate (IS)
• Testosteronönanthat (IS)
• UNII-7Z6522T8N9 (IS)
• Testostérone (énantate de) (PH: Ph. Eur. 6)
• Testosterone Enantate (PH: BP 2010, Ph. Int. 4, Ph. Eur. 6)
• Testosterone Enanthate (PH: USP 32, JP XIV)
• Testosteronenantat (PH: Ph. Eur. 6)
• Testosteroni enantas (PH: Ph. Int. 4, Ph. Eur. 6)
• Testosterone Phenylpropionate (OS: BANM)
• Testosterone Phenylpropionate (PH: BP vet. 2007)
• Testosterone Propionate (OS: JAN, BANM)
• Androlon (IS)
• Andronate (IS)
• Androteston (IS)
• Andrusol P (IS)
• Andrusol-P (IS)
• Anertan (IS)
• Depot Androteston (IS)
• Enarmon (IS)
• Homandren (IS)
• Hormoteston (IS)
• Masenate (IS)
• Orchiol (IS)
• Orchistin (IS)
• Oreton propionate (IS)
• Pantestin (IS)
• Primotestone (IS)
• Propiokan (IS)
• Sterandryl (IS)
• Suprasteron (IS)
• Synandrol (IS)
• Syndren (IS)
• Synerone (IS)
• Testormon (IS)
• Testosid (IS)
• Testoxyl (IS)
• Testostérone (propionate de) (PH: Ph. Eur. 6)
• Testosterone Propionate (PH: BP 2010, JP XIV, Ph. Int. 4, USP 32, Ph. Eur. 6)
• Testosteroni propionas (PH: Ph. Int. 4, Ph. Eur. 6)
• Testosteronpropionat (PH: Ph. Eur. 6)
• Testosterone Undecanoate (OS: BANM, USAN)
• 4-08-00-00981 (IS: Beilstein)
• BRN 3176734 (IS)
• EINECS 227-712-6 (IS)
• Org 538 (IS)
• Testosterone 17ß-undecylate (IS)

Brand Names

• Androderm
  Hospira, Australia; Hospira, New Zealand; Paladin, Canada; Watson, United States



• Androgel
  Besins, Belgium; Besins, Bulgaria; Besins, Bahrain; Besins, Estonia; Besins, Georgia; Besins, Hungary; Besins, Israel; Besins, Italy; Besins, Lithuania; Besins, Luxembourg; Besins, Latvia; Besins, Malta; Besins, Netherlands; Besins, Russian Federation; Besins, Vietnam; Biopas, Peru; Euro, Netherlands; Laboratoires Besins, Slovakia; Medcor, Netherlands; Solvay, Canada; Solvay, France; Solvay, Croatia (Hrvatska); Unimed, United States



• Androlone
  Beta, Argentina



• Andropatch
  GlaxoSmithKline, United Kingdom



• Androtag
  Rontag, Argentina



• Androtardyl
  Schering, Tunisia



• Androtop
  Besins, Poland; Solvay, Germany



• Atmos
  AstraZeneca, Iceland



• Bothermon (Testosterone and Estradiol)
  ASKA SeiyakuAsuka, Japan



• Esjin (Testosterone and Estradiol)
  Fuji Yakuhin, Japan



• Fortigel
  ProStrakan, France



• Intrinsa
  Procter & Gamble, Germany; Procter & Gamble, France; Procter & Gamble, United Kingdom; Procter & Gamble, Italy; Procter & Gamble, Netherlands; Procter & Gamble, Sweden; Procter Gamble, Spain



• Itnogen
  LCA, Belgium; Prostrakan Farmaceutica, Spain



• Lowtiyel
  Italmex, Mexico



• Nebido
  Schering, Argentina; Schering, Chile



• Pantestone
  Organon, Tunisia



• Striant
  Ardana Bioschience Limited, Luxembourg; Columbia, United States



• Sustanon
  Organon, Estonia



• Sustenan
  Organon, Chile



• Sustogen
  Techno, Bangladesh



• Testim
  Auxilium, United States; Ferring, Sweden; Ipsen, Belgium; Ipsen, Germany; Ipsen, Denmark; Ipsen, Spain; Ipsen, Finland; Ipsen, United Kingdom; Ipsen, Ireland; Ipsen, Italy; Ipsen, Luxembourg; Ipsen, Netherlands; Paladin, Canada



• Testocaps
  Organon, Chile



• Testocur
  Wolff, Germany



• Testogel
  Bayer, Switzerland; Bayer, Germany; Bayer, Spain; Bayer, United Kingdom; Bayer, Sweden; Bayer, Turkey; Bayer Schering, Australia; Bayer Schering, Finland; Bayer Schering, Ireland; Besins, Austria; Besins, Denmark; Besins, Iceland; Besins, Italy; Besins, Luxembourg; BESINS INTERNATIONAL, Norway; Schering, Portugal



• Testopatch
  Pierre Fabre, Germany; Pierre Fabre, Spain; Pierre Fabre, Poland; Pierre Fabre Médicament, France



• Testopel
  Slate, United States



• Testosterone Implant
  Organon, United Kingdom; Organon, Singapore



• Testosterone Implants
  Adcock Ingram Pharmaceuticals, South Africa; Organon, Australia; Organon, New Zealand



• Testosterone
  Watson, United States



• Testosterone (veterinary use)
  RWR Veterinary Products, Australia



• Tostran
  APS, Germany; Clonmel, Ireland; Ferring, Hungary; Ferring, Poland; Medius, Switzerland; Prostrakan, Czech Republic; Prostrakan, Denmark; Prostrakan, United Kingdom; Prostrakan, Netherlands; Prostrakan, Norway



• Tostrex
  ProStrakan, Sweden



• Y-45
  Incepta, Bangladesh



• Depo-Testosterone
  Pfizer, Canada; Pfizer, New Zealand; Pfizer, Singapore; Pfizer, United States; Pfizer, South Africa



• Depotrone
  Adcock Ingram Pharmaceuticals, South Africa



• Testosterone Cypionate
  Paddock, United States; Sandoz, United States; Synerx, United States; Tai Yu, Taiwan; Teva USA, United States; Watson, United States



• Andriol
  Organon, Vietnam



• Andriol-T
  Organon, Portugal



• Durateston (veterinary use)
  Intervet, South Africa



• Nebido
  Bayer Animal Health, Luxembourg; Schering, Antigua & Barbuda; Schering, Netherlands Antilles; Schering, Aruba; Schering, Barbados; Schering, Bermuda; Schering, Bahamas; Schering, Belize; Schering, Colombia; Schering, Grenada; Schering, Guyana; Schering, Haiti; Schering, Jamaica; Schering, Cayman Islands; Schering, Saint Lucia; Schering, Malta; Schering, Suriname; Schering, Trinidad & Tobago



• Sustanon
  Organon, Indonesia



• Testocaps
  Organon, Luxembourg



• Androtardyl
  Bayer Santé, France; Schering, Burkina Faso; Schering, Benin; Schering, Central African Republic; Schering, Congo; Schering, Cote D'ivoire; Schering, Algeria; Schering, Mali; Schering, Mauritius; Schering, Niger; Schering, Senegal; Schering, Togo



• Delatestryl
  Endo, United States; Savient, United States; Theramed, Canada



• Despamen (Testosterone and Estradiol valerate)
  Emdiex S.A., Peru



• Dihormon (Testosterone and Estradiol)
  Mochida, Japan



• Enarmon
  ASKA SeiyakuAsuka, Japan



• Jenasteron
  Jenapharm, Malaysia



• Panteston
  Organon, Peru



• Primodian Depot (Testosterone and Estradiol)
  Bayer Schering, South Africa



• Primodian (Testosterone and Estradiol)
  Fuji Yakuhin, Japan



• Primoniat Depot
  Schering, Chile



• Primoteston Depot
  Bayer Schering, Australia



• Ropel Liquid Testosterone (veterinary use)
  Jurox, Australia



• Testinon Depot
  Mochida, Japan



• Testo-Enant
  Geymonat, Italy



• Testosteron depo
  Galenika, Bosnia & Herzegowina; Galenika, Serbia



• Testosteron Depot Eifelfango
  Eifelfango, Germany



• Testosteron Depot Galen
  Galenpharma, Germany; TAD, Germany



• Testosteron Depot Jenapharm
  Bayer, Germany



• Testosteron Depot-Rotexmedica
  Rotexmedica, Germany



• Testosterona Enantato L.CH.
  Chile, Chile



• Testosterone Enantate
  Cambridge Laboratories, United Kingdom; Paddock, United States



• Testosterone Enanthate
  Synerx, United States; Watson, United States



• Testosterone heptylate SERP
  SERP, Burkina Faso; SERP, Benin; SERP, Central African Republic; SERP, Congo; SERP, Cote D'ivoire; SERP, Cameroon; SERP, Gabon; SERP, Guinea; SERP, Madagascar; SERP, Mali; SERP, Mauritania; SERP, Mauritius; SERP, Niger; SERP, Senegal; SERP, Chad; SERP, Togo



• Testosteronum
  Jelfa, Poland



• Testoviron
  Bayer Schering, Greece; Schering, Argentina; Schering, Colombia; Schering, Oman



• Testoviron Depot
  Bayer, Switzerland; Bayer, Germany; Schering, Argentina; Schering, Hong Kong; Schering, Israel; Schering, Iceland; Schering, Sri Lanka; Schering, Luxembourg; Schering, Peru; Schering, Thailand



• Testron Depot
  Fuji Yakuhin, Japan



• Agovirin Depot
  Biotika, Czech Republic



• Agovirin
  Biotika, Slovakia



• Folivirin (Testosterone and Estradiol)
  Biotika, Slovakia



• Testanon 50
  Organon, India



• Enarmon
  ASKA SeiyakuAsuka, Japan



• Pasoma
  E. Merck, Ethiopia



• Progro H (Testosterone and Estradiol (veterinary use))
  Pro Beef Australia, Australia



• Synovex (Testosterone and Estradiol (veterinary use))
  Fort Dodge Animale Health, United States; Fort Dodge Australia, Australia



• Tepro (veterinary use)
  Virbac, Australia



• Testanon 25
  Organon, India



• Testoprop (veterinary use)
  Jurox, Australia



• Testovis
  SIT, Italy



• Virormone
  Nordic, United Arab Emirates; Nordic, Bahrain; Nordic, Egypt; Nordic, Iraq; Nordic, Iran; Nordic, Jordan; Nordic, Kuwait; Nordic, Lebanon; Nordic, Oman; Nordic, Qatar; Nordic, Saudi Arabia; Nordic, Syria; Nordic, Yemen; Nordic Pharma, United Kingdom; Paines & Byrne, Cyprus; Paines & Byrne, Libya



• Durateston
  Organon, Brazil



• Durateston (veterinary use)
  Intervet, Belgium; Intervet, United Kingdom; Intervet/Schering-Plough Animal Health, Australia



• Omnadren
  Jelfa, Georgia; Jelfa, Latvia; Jelfa, Poland; Jelfa, Russian Federation



• Sustanon
  Organon, United Arab Emirates; Organon, Argentina; Organon, Australia; Organon, Australia; Organon, Bangladesh; Organon, Belgium; Organon, Bahrain; Organon, Cyprus; Organon, Czech Republic; Organon, Egypt; Organon, Finland; Organon, Ghana; Organon, Hong Kong; Organon, Ireland; Organon, Ireland; Organon, Israel; Organon, India; Organon, India; Organon, Iraq; Organon, Iran; Organon, Italy; Organon, Jordan; Organon, Kenya; Organon, Kuwait; Organon, Lebanon; Organon, Lithuania; Organon, Latvia; Organon, Libya; Organon, Netherlands; Organon, Oman; Organon, Oman; Organon, Qatar; Organon, Saudi Arabia; Organon, Sudan; Organon, Singapore; Organon, Slovakia; Organon, Syria; Organon, Turkey; Organon, Tanzania; Organon, Yemen; Organon, Zambia; Organon, Zimbabwe; Pharmaco, New Zealand; Schering-Plough, United Kingdom



• Testex Elmu
  Q-Pharma, Spain



• Testoviron Depot
  German Remedies, India; Schering, United Arab Emirates; Schering, Bahrain; Schering, Cyprus; Schering, Egypt; Schering, Ethiopia; Schering, Ireland; Schering, Iraq; Schering, Iceland; Schering, Jordan; Schering, Kuwait; Schering, Lebanon; Schering, Libya; Schering, Qatar; Schering, Saudi Arabia; Schering, Sudan; Schering, Yemen



• Testoviron
  Schering, Italy



• Testoviron-Depot Paranova
  Bayer Schering Pharma, Denmark



• Andriol Testocaps
  Organon, Austria; Organon, Indonesia; Organon, Vietnam



• Andriol
  Essex, Germany; Essex Chemie, Switzerland; EU-Pharma, Netherlands; Eureco, Netherlands; Euro, Netherlands; Organon, United Arab Emirates; Organon, Australia; Organon, Bangladesh; Organon, Canada; Organon, China; Organon, Cyprus; Organon, Denmark; Organon, Estonia; Organon, Egypt; Organon, Ghana; Organon, Hong Kong; Organon, Hungary; Organon, Iraq; Organon, Iran; Organon, Italy; Organon, Jordan; Organon, Kenya; Organon, Kuwait; Organon, Lebanon; Organon, Sri Lanka; Organon, Latvia; Organon, Libya; Organon, Mexico; Organon, Netherlands; Organon, Norway; Organon, Oman; Organon, Philippines; Organon, Qatar; Organon, Serbia; Organon, Saudi Arabia; Organon, Singapore; Organon, Syria; Organon, Thailand; Organon, Taiwan; Organon, Tanzania; Organon, Venezuela; Organon, Yemen; Organon, Zambia; Organon, Zimbabwe



• Androxon
  Adcock Ingram Pharmaceuticals, South Africa; Organon, Brazil; Organon, Israel



• Nebid
  Bayer, Italy



• Nebido
  Bayer, Austria; Bayer, Belgium; Bayer, Switzerland; Bayer, Germany; Bayer, United Kingdom; Bayer, Greece; Bayer, Croatia (Hrvatska); Bayer, Latvia; Bayer, Sweden; Bayer, Singapore; Bayer, Turkey; Bayer Santé, France; Bayer Schering, Finland; Bayer Schering, Indonesia; Bayer Schering, Ireland; Bayer Schering, South Africa; Bayer Schering Pharma, Denmark; Bayer Schering Pharma, Norway; Schering, Czech Republic; Schering, Estonia; Schering, Hungary; Schering, Iceland; Schering, Lithuania; Schering, Mexico; Schering, Philippines; Schering, Poland; Schering, Portugal; Schering, Romania; Schering, Serbia; Schering, Russian Federation; Schering, Slovenia; Schering, Slovakia



• Numanis
  Bayer, Spain



• Nuvir
  Organon, India



• Panteston
  Organon, Finland; Organon, New Zealand



• Pantestone
  Schering-Plough, France



• Reandron
  Bayer, Spain; Bayer, New Zealand; Bayer Australia Ltd, Australia



• Restandol Orifarm
  Organon, Denmark



• Restandol
  Organon, Greece; Organon, Ireland; Organon, Malta; Schering-Plough, United Kingdom



• Testocaps
  Organon, Belgium



• Undestor
  Organon, Argentina; Organon, Czech Republic; Organon, Luxembourg; Organon, Poland; Organon, Romania; Organon, Slovakia



• Undestor Testocaps
  Schering-Plough, Sweden



• Virigen
  Organon, Turkey

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
SPC	Summary of Product Characteristics (UK)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Apo-Pimozide

Apo-Pimozide may be available in the countries listed below.

Ingredient matches for Apo-Pimozide

Pimozide

Pimozide is reported as an ingredient of Apo-Pimozide in the following countries:

• Canada

International Drug Name Search

Cefpodoxime Sandoz

Cefpodoxime Sandoz may be available in the countries listed below.

Ingredient matches for Cefpodoxime Sandoz

Cefpodoxime

Cefpodoxime proxetil (a derivative of Cefpodoxime) is reported as an ingredient of Cefpodoxime Sandoz in the following countries:

• France

International Drug Name Search

Dynacirc CR

Generic Name: isradipine (Oral route)

is-RAD-i-peen

Commonly used brand name(s)

In the U.S.

• Dynacirc


• Dynacirc CR

Available Dosage Forms:

• Tablet


• Tablet, Extended Release


• Capsule

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Dihydropyridine

Uses For Dynacirc CR

Isradipine is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Isradipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, isradipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .

Before Using Dynacirc CR

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of isradipine in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of isradipine in the elderly. However, elderly patients are more likely to have liver or kidney problems which may require an adjustment of dose in patients receiving isradipine .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil


• Cisapride


• Levomethadyl


• Mefloquine


• Mesoridazine


• Pimozide


• Thioridazine


• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide


• Acetophenazine


• Ajmaline


• Amiodarone


• Amisulpride


• Amitriptyline


• Amoxapine


• Aprindine


• Arsenic Trioxide


• Astemizole


• Azimilide


• Bretylium


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Clarithromycin


• Dantrolene


• Desipramine


• Dibenzepin


• Disopyramide


• Dofetilide


• Dolasetron


• Doxepin


• Droperidol


• Encainide


• Enflurane


• Erythromycin


• Ethopropazine


• Flecainide


• Fluconazole


• Fluoxetine


• Fluphenazine


• Foscarnet


• Gemifloxacin


• Halofantrine


• Haloperidol


• Halothane


• Hydroquinidine


• Ibutilide


• Imipramine


• Isoflurane


• Lidoflazine


• Lorcainide


• Methotrimeprazine


• Nortriptyline


• Octreotide


• Ondansetron


• Pentamidine


• Perphenazine


• Pipotiazine


• Pirmenol


• Prajmaline


• Probucol


• Procainamide


• Prochlorperazine


• Promazine


• Promethazine


• Propafenone


• Propiomazine


• Protriptyline


• Quetiapine


• Quinidine


• Risperidone


• Sematilide


• Sertindole


• Sotalol


• Spiramycin


• Sulfamethoxazole


• Sultopride


• Tedisamil


• Telithromycin


• Terfenadine


• Thiethylperazine


• Trifluoperazine


• Triflupromazine


• Trimeprazine


• Trimethoprim


• Trimipramine


• Vasopressin


• Zolmitriptan


• Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amprenavir


• Dalfopristin


• Indinavir


• Itraconazole


• Ketoconazole


• Magnesium


• Quinupristin


• Rifampin


• Rifapentine


• St John's Wort

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bowel blockage or


• Congestive heart failure—Use with caution. May make these conditions worse .

• Kidney disease or


• Liver disease—Use with caution. The effects of isradipine may be increased because of the slower removal of the medicine from the body .

Proper Use of isradipine

This section provides information on the proper use of a number of products that contain isradipine. It may not be specific to Dynacirc CR. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet whole with a full glass of water. Do not break, crush, or chew it .

If you are taking the extended-release tablets, part of the tablet may pass into your stools after your body has absorbed the medicine. This is normal and is nothing to worry about .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For high blood pressure:
  
  • For oral dosage form (capsules):
    
    • Adults—At first, 2.5 milligrams (mg) twice a day. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 5 milligrams (mg) once a day. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Dynacirc CR

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

Low blood pressure (hypotension) may occur while taking this medicine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness .

This medicine may cause fluid retention (edema) in some patients. Tell your doctor right away if you have bloating or swelling of face, arms, hands, lower legs, or feet; tingling of hands or feet; or unusual weight gain or loss .

Dynacirc CR Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bloating or swelling of face, arms, hands, lower legs, or feet


• tingling of hands or feet


• unusual weight gain or loss

Less common

• Chest pain


• difficult or labored breathing


• dizziness


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling of warmth


• full or bloated feeling


• nausea


• pressure in the stomach


• redness of the face, neck, arms and occasionally, upper chest


• shortness of breath


• swelling of abdominal or stomach area


• tightness in chest


• unusual tiredness or weakness


• vomiting


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

• Blurred vision


• confusion


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• flushing


• sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache

Less common

• Diarrhea


• difficulty having a bowel movement (stool)


• rash


• stomach soreness or discomfort

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dynacirc CR side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Dynacirc CR resources

• Dynacirc CR Side Effects (in more detail)
• Dynacirc CR Use in Pregnancy & Breastfeeding
• Drug Images
• Dynacirc CR Drug Interactions
• Dynacirc CR Support Group
• 1 Review for Dynacirc CR - Add your own review/rating

• Dynacirc CR Concise Consumer Information (Cerner Multum)


• Isradipine Prescribing Information (FDA)


• Isradipine MedFacts Consumer Leaflet (Wolters Kluwer)


• Isradipine Professional Patient Advice (Wolters Kluwer)


• Isradipine Monograph (AHFS DI)


• DynaCirc Prescribing Information (FDA)


• DynaCirc CR Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• DynaCirc CR Prescribing Information (FDA)

Compare Dynacirc CR with other medications

• Angina Pectoris Prophylaxis
• High Blood Pressure
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Gentamicina ClNa Baxter

Gentamicina ClNa Baxter may be available in the countries listed below.

Ingredient matches for Gentamicina ClNa Baxter

Gentamicin

Gentamicin sulfate (a derivative of Gentamicin) is reported as an ingredient of Gentamicina ClNa Baxter in the following countries:

• Spain

International Drug Name Search

Garesirol

Garesirol may be available in the countries listed below.

Ingredient matches for Garesirol

Tranilast

Tranilast is reported as an ingredient of Garesirol in the following countries:

• Japan

International Drug Name Search

Lecoruc

Lecoruc may be available in the countries listed below.

Ingredient matches for Lecoruc

Chlormadinone

Chlormadinone 17α-acetate (a derivative of Chlormadinone) is reported as an ingredient of Lecoruc in the following countries:

• Japan

International Drug Name Search

Disnal

Disnal may be available in the countries listed below.

Ingredient matches for Disnal

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Disnal in the following countries:

• Spain

Colecalciferol

Colecalciferol is reported as an ingredient of Disnal in the following countries:

• Spain

International Drug Name Search

Bemegride

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

R07AB05

CAS registry number (Chemical Abstracts Service)

0000064-65-3

Chemical Formula

C8-H13-N-O2

Molecular Weight

155

Therapeutic Category

Analeptic

Chemical Name

2,6-Piperidinedione, 4-ethyl-4-methyl-

Foreign Names

• Bemegridum (Latin)
• Bemegrid (German)
• Bémégride (French)
• Bemegrida (Spanish)

Generic Names

• Bemegride (OS: JAN, BAN)
• Bémégride (OS: DCF)
• Methetharimide (IS)
• Methylaethylglutarimid (IS)
• NP 13 (IS)
• Bemegride (PH: BP 1968)

Brand Name

• Megibal
  Tanabe Mitsubishi, Japan

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Tera TAD

Tera TAD may be available in the countries listed below.

Ingredient matches for Tera TAD

Terazosin

Terazosin hydrochloride (a derivative of Terazosin) is reported as an ingredient of Tera TAD in the following countries:

• Germany

International Drug Name Search

Anti-Kalium Na

Anti-Kalium Na may be available in the countries listed below.

Ingredient matches for Anti-Kalium Na

Polystyrene Sulfonic Acid

Polystyrene Sulfonic Acid sodium salt (a derivative of Polystyrene Sulfonic Acid) is reported as an ingredient of Anti-Kalium Na in the following countries:

• Germany

International Drug Name Search

O.T.C. 10

O.T.C. 10 may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for O.T.C. 10

Oxytetracycline

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of O.T.C. 10 in the following countries:

• Netherlands

International Drug Name Search

Digilanogen C

Digilanogen C may be available in the countries listed below.

Ingredient matches for Digilanogen C

Deslanoside

Deslanoside is reported as an ingredient of Digilanogen C in the following countries:

• Japan

Lanatoside C

Lanatoside C is reported as an ingredient of Digilanogen C in the following countries:

• Japan

International Drug Name Search

Sufisal

Sufisal may be available in the countries listed below.

Ingredient matches for Sufisal

Pentoxifylline

Pentoxifylline is reported as an ingredient of Sufisal in the following countries:

• Dominican Republic


• El Salvador


• Guatemala


• Honduras


• Mexico


• Nicaragua

International Drug Name Search

Diaz

Diaz may be available in the countries listed below.

Ingredient matches for Diaz

Diazepam

Diazepam is reported as an ingredient of Diaz in the following countries:

• Israel

International Drug Name Search

Deuron

Deuron may be available in the countries listed below.

Ingredient matches for Deuron

Benzbromarone

Benzbromarone is reported as an ingredient of Deuron in the following countries:

• Taiwan

International Drug Name Search

Ibuprofen elac

Ibuprofen elac may be available in the countries listed below.

Ingredient matches for Ibuprofen elac

Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofen elac in the following countries:

• Germany

International Drug Name Search

Cabergolin Sandoz

Cabergolin Sandoz may be available in the countries listed below.

Ingredient matches for Cabergolin Sandoz

Cabergoline

Cabergoline is reported as an ingredient of Cabergolin Sandoz in the following countries:

• Austria


• Germany

International Drug Name Search

Mei Su Yu

Mei Su Yu may be available in the countries listed below.

Ingredient matches for Mei Su Yu

Trazodone

Trazodone hydrochloride (a derivative of Trazodone) is reported as an ingredient of Mei Su Yu in the following countries:

• China

International Drug Name Search

Amebidal

Amebidal may be available in the countries listed below.

Ingredient matches for Amebidal

Metronidazole

Metronidazole benzoate (a derivative of Metronidazole) is reported as an ingredient of Amebidal in the following countries:

• Mexico

International Drug Name Search

Dexadreson

Dexadreson may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Dexadreson

Dexamethasone

Dexamethasone 21-(disodium phosphate) (a derivative of Dexamethasone) is reported as an ingredient of Dexadreson in the following countries:

• Australia


• France


• Ireland


• Italy


• Netherlands


• New Zealand


• Sweden


• Switzerland


• United Kingdom

Dexamethasone phenylpropionate and 21-(disodium phosphate) (a derivative of Dexamethasone) is reported as an ingredient of Dexadreson in the following countries:

• Germany

International Drug Name Search

Ranitidin Actavis

Ranitidin-Actavis may be available in the countries listed below.

Ingredient matches for Ranitidin-Actavis

Ranitidine

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranitidin-Actavis in the following countries:

• Germany


• Sweden

International Drug Name Search

Uracyst Test Kit

Uracyst Test Kit may be available in the countries listed below.

Ingredient matches for Uracyst Test Kit

Chondroitin Polysulfate

Chondroitin Polysulfate sodium salt (a derivative of Chondroitin Polysulfate) is reported as an ingredient of Uracyst Test Kit in the following countries:

• Canada

Potassium Chloride

Potassium Chloride is reported as an ingredient of Uracyst Test Kit in the following countries:

• Canada

International Drug Name Search

Sarve

Sarve may be available in the countries listed below.

Ingredient matches for Sarve

Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Sarve in the following countries:

• Poland

International Drug Name Search

Broncodil

Broncodil may be available in the countries listed below.

Ingredient matches for Broncodil

Salbutamol

Salbutamol sulfate (a derivative of Salbutamol) is reported as an ingredient of Broncodil in the following countries:

• Sri Lanka

International Drug Name Search

Isosorbide Mononitrato DOC

Isosorbide Mononitrato DOC may be available in the countries listed below.

Ingredient matches for Isosorbide Mononitrato DOC

Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isosorbide Mononitrato DOC in the following countries:

• Italy

International Drug Name Search

Clotrimazolo DOC

Clotrimazolo DOC may be available in the countries listed below.

Ingredient matches for Clotrimazolo DOC

Clotrimazole

Clotrimazole is reported as an ingredient of Clotrimazolo DOC in the following countries:

• Italy

International Drug Name Search

Radiogardase

In the US, Radiogardase (prussian blue systemic) is a member of the drug class antidotes.

US matches:

• Radiogardase

Ingredient matches for Radiogardase

Prussian Blue

Prussian Blue is reported as an ingredient of Radiogardase in the following countries:

• Germany


• United States

International Drug Name Search

Hypothiazid

Hypothiazid may be available in the countries listed below.

Ingredient matches for Hypothiazid

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Hypothiazid in the following countries:

• Bulgaria


• Estonia


• Georgia


• Hungary


• Latvia


• Lithuania


• Russian Federation

International Drug Name Search

Lexil

Lexil may be available in the countries listed below.

Ingredient matches for Lexil

Bromazepam

Bromazepam is reported as an ingredient of Lexil in the following countries:

• Italy

Propantheline

Propantheline Bromide is reported as an ingredient of Lexil in the following countries:

• Italy

International Drug Name Search

Cipro

In the US, Cipro (ciprofloxacin systemic) is a member of the drug class quinolones and is used to treat Anthrax, Anthrax Prophylaxis, Bacteremia, Bacterial Infection, Bladder Infection, Bone infection, Bronchitis, Chancroid, Cholera, Crohn's Disease, Cutaneous Bacillus anthracis, Diverticulitis, Febrile Neutropenia, Gonococcal Infection - Disseminated, Gonococcal Infection - Uncomplicated, Granuloma Inguinale, Infection Prophylaxis, Infectious Diarrhea, Intraabdominal Infection, Joint Infection, Kidney Infections, Meningococcal Meningitis Prophylaxis, Mycobacterium avium-intracellulare - Treatment, Nosocomial Pneumonia, Peritonitis, Plague, Pneumonia, Pneumonia with Cystic Fibrosis, Prostatitis, Rabbit Fever, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Sinusitis, Skin Infection, Traveler's Diarrhea, Tuberculosis - Active, Typhoid Fever and Urinary Tract Infection.

US matches:

• Cipro


• Cipro HC Otic


• Cipro I.V.


• Cipro Suspension


• Cipro XR Extended-Release Tablets


• Cipro HC


• Cipro XR


• Cipro IV


• Cipro Iv Minibags

Ingredient matches for Cipro

Ciprofloxacin

Ciprofloxacin is reported as an ingredient of Cipro in the following countries:

• Argentina


• Colombia


• Peru


• Tunisia


• United States

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Cipro in the following countries:

• Argentina


• Brazil


• Canada


• Colombia


• Georgia


• Turkey


• United States

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Cipro in the following countries:

• Colombia


• United States

International Drug Name Search

Hemohes

Hemohes may be available in the countries listed below.

Ingredient matches for Hemohes

Hetastarch

Hetastarch is reported as an ingredient of Hemohes in the following countries:

• Austria


• Chile


• Estonia


• Finland


• Germany


• Iceland


• Latvia


• Luxembourg


• Netherlands


• Slovenia


• Spain


• Switzerland


• Taiwan


• Turkey

International Drug Name Search

DryMax Syrup

chlorpheniramine maleate, methscopolamine nitrate and pseudoephedrine hydrochloride

Dosage Form: syrup
DryMax Syrup

DryMax Syrup

Rx Only


DESCRIPTION: Each teaspoonful (5 mL) for oral administration contains:

Chlorpheniramine Maleate.................................. 4 mg

Methscopolamine Nitrate................................. 1.25 mg

Pseudoephedrine Hydrochloride......................... 30 mg


Inactive ingredients: Purified Water, Citric Acid, Sodium Citrate, Sodium Saccharin, Sucrose, Grape Flavor,

Bitter Mask, FD and C Red #40, FD and C Blue #1, Propylene Glycol, Glycerin.


DryMax Syrup contains ingredients from the following classes: antihistamine, anticholinergic, and nasal

decongestant.


Chlorpheniramine Maleate is an antihistamine with the chemical name 2-Pyridinepropanamine, γ-(4-chlorphenyl)-N,

N-dimethyl-, (Z)-2-butendioate (1:1) 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine (1:1).


Methscopolamine Nitrate is an anticholinergic belladonna alkaloid derivative with the chemical name: 3-Oxa-9-

azoniatricyclo(3.3.1.02,4)nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, nitrate. [7(s)-1α, 2β-4β-5α-7β].


Pseudoephedrine Hydrochloride is a nasal decongestant with the chemical name Benzenemethanol,α-[1-

(methylamino)ethyl]-, [S-(R*, R*)-, hydrochloride.

CLINICAL PHARMACOLOGY:

Chlorpheniramine maleate competitively antagonizes most of the smooth muscle stimulating actions of histamine

on the H1 receptors of the GI tract, uterus, large blood vessels, and bronchial muscle. It also antagonizes the action

of histamine that results in increased capillary permeability and the formation of edema. Chlorpheniramine maleate

is an alkylamine-type antihistamine. This group of antihistamines are among the most active histamine antagonists

and are generally effective in relatively low doses. They thereby prevent, but do not reverse, responses mediated by

histamine alone. The anticholinergic actions of most antihistamines provide a drying effect on the nasal mucosa.

These drugs are not so prone to produce drowsiness and are among the most suitable agents for daytime use, but

a significant proportion of patients do experience this effect.


Methscopolamine Nitrate is one of the principal anticholinergic/antispasmodic components of belladonna alkaloids

that exhibits antisecretory activity. Methscopolamine inhibits the muscarinic actions of acetylcholine on structures

innervated by postganglionic cholinergic nerves: smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes,

and exocrine glands. In general, the smaller doses of anticholinergics inhibit salivary and bronchial secretions, sweating,

and accommodation; cause dilation of the pupil; and may affect the heart rate.


Pseudoephedrine hydrochloride is an oral sympathomimetic amine that acts as a decongestant to respiratory tract

mucous membranes. While its vasoconstrictor action is similar to that of ephedrine, pseudoephedrine has less pressor

effect in normotensive adults. Serum half-life for pseudoephedrine is 6 to 8 hours. Acidic urine is associated with faster

elimination of the drug. About one-half of the administered drug is excreted in the urine.

INDICATIONS:

This product provides relief of the symptoms resulting from irritation of sinus, nasal, and upper respiratory

tract tissue. Pseudoephedrine exerts a vasoconstrictive and decongestive action while chlorpheniramine

maleate decreases the symptoms of watering eyes, post-nasal drip, and sneezing. Methscopolamine nitrate

further augments the antisecretory activity of this product.

CONTRAINDICATIONS:

This product is contraindicated in patients with hypersensitivity or idiosyncrasy to any of its ingredients. It is

also contraindicated in women who are pregnant or nursing. This product is contraindicated in children under

six years of age, because this age group is sensitive to the effects of sympathomimetic amines.


It is also contraindicated in newborn or premature infants, because this age group has an increased susceptibility

to the anticholinergic side effects of chlorpheniramine maleate. Geriatric patients may be more sensitive to the

effects of this medication.


Risk-benefit should be considered when the following conditions exist: Acute asthma; Bladder neck obstruction;

Brain damage in children; Cardiac disease, especially cardiac arrhythmias, congestive heart failure, coronary

artery disease, and mitral stenosis; Cardiovascular disease; Diabetes mellitus; Down's Syndrome; Esophagitis,

reflux; Narrow angle glaucoma; Acute hemorrhage with unstable cardiovascular status; Hepatic function

impairment; Hernia; Hypertension; Hyperthyroidism; Intestinal atony in the elderly or debilitated patient; Chronic

lung disease; Myasthenia gravis; Autonomic neuropathy; Paralytic ileus; Prostatic hypertrophy; Psychiatric

disorders; Pyloric obstruction; Renal function impairment; Spastic paralysis, in children; Tachycardia; Toxemia

of pregnancy; Ulcerative colitis; Urinary retention, or predisposition to; Uropathy; Xerostomia.

WARNINGS:

This product may cause drowsiness or blurred vision. Patients taking this product should be warned not

to engage in activities requiring mental alertness such as operating a motor vehicle or other machinery or

to perform hazardous tasks while taking this drug.


Sympathomimetic amines should be used with caution in patients with hypertension, ischemic heart disease,

diabetes mellitus, increased intraocular pressure, hyperthyroidism, or prostatic hypertrophy. The overdosage

of sympathomimetic amines may produce CNS stimulation with convulsions or cardiovascular collapse with

accompanying hypotension. Do not exceed recommended dosage.


Heat prostration can occur with the use of methscopolamine when the environmental temperature is high.

Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy

or colostomy; in this instance, use of methscopolamine would be inappropriate and possibly harmful.

PRECAUTIONS: General:

Use Pseudoephedrine with caution in patients with hypoxia, acidosis, or a history of arteriosclerosis,

bradycardia, partial heart block, hypertension, myocardial disease, thrombosis, or ventricular tachycardia.

Antihistamines have an atropine-like action and should be used with caution in patients with a history of

bronchial asthma, emphysema, increased intraocular pressure, hyperthyroidism, cardiovascular disease and

hypertension.


Use methscopolamine with caution in patients with hiatal hernia associated with reflux Esophagitis. Use

extreme caution and only when needed in patients with autonomic neuropathy, hyperthyroidism, coronary

heart disease, congestive heart failure, and cardiac arrhythmia.

Information for Patients:

Patient consultation should include the following information regarding proper use of this medication:

• Do not take more medication than the amount recommended.


• This medication should be used with caution during exercise or hot weather, overheating may result in heat stroke.


• Do not drive or operate machinery if drowsiness or dizziness occurs.


• Do not ingest alcoholic beverages, monoamine oxidase (MAO) inhibitors, or CNS depression-producing medications (hypnotics, sedatives, tranquilizers) while taking this medication.


• This medication possibly increases sensitivity of eyes to light.
  


• Methscopolamine nitrate may cause blurred vision.


• If a dose is missed, the medication should be taken as soon as possible unless it is almost time for the next dose. Do not double doses.


• This medication should be stored in a tight, light-resistant container at temperatures between 15o-30oC (59o-86oF).


• Keep all medications out of reach of children. In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Caution patients about the signs of potential side effects, especially:


• Anticholinergic effects - clumsiness or unsteadiness; severe drowsiness; severe dryness of mouth, nose, or throat; flushing or redness of face; shortness of breath or trouble breathing.


• Blood dyscrasias-sore throat and fever; unusual bleeding or bruising; unusual tiredness or weakness.


• Fast or irregular heartbeat.


• Psychotic episodes.


• Tightness in chest.

Note: When anticholinergics are given to patients, especially children, where the environmental temperature is high

there is a risk of a rapid increase in body temperature because of suppression of sweat gland activity. Infants, patients

with Down's syndrome, and children with spastic paralysis or brain damage may show an increased response to

anticholinergics, thus increasing the potential for side effects.


Geriatric or debilitated patients may respond to usual doses of anticholinergics with excitement, agitation, drowsiness,

or confusion.

Laboratory Tests:

The following may be especially important in patient monitoring (other tests may be warranted in some patients,

depending on conditions): Blood pressure determination - recommended at frequent intervals during therapy:

Electrocardiogram (ECG) - monitoring may be required: Intraocular pressure determination - recommended at

periodic intervals, as these medications may increase the intraocular pressure.

Drug Interactions:

Do not take this product if you are presently taking, or have taken within the preceding two weeks, a prescription

drug for high blood pressure or depression without first consulting your physician. Absorption of other oral

medications may be decreased during concurrent use with anticholinergics due to decreased gastrointestinal

motility and delayed gastric emptying.

Combinations containing any or the following medications, depending on the amount present, may also interact

with this product:

• Alkalizers, such as: calcium and/or magnesium-containing antacids; Carbonic anhydrase inhibitors; citrates; sodium bicarbonate-urinary excretion of anticholinergics may be delayed by alkalization of the urine, thus potentiating methscopolamine's therapeutic and/or side effects.


• α-adrenergic blocking agents or other medications with α-adrenergic blocking action - prior to administration of α-adrenergics may block the pressor response to pseudoephedrine, possibly resulting in severe hypotension; medications with α-adrenergic blocking action may decrease the pressor effect and shorten the duration of action of pseudoephedrine.


• Antacids or absorbent antidiarrheals-simultaneous use of these medications may reduce absorption of methscopolamine, resulting in decreased therapeutic effectiveness; doses of these medications should be spaced 2 or 3 hours apart from doses of methscopolamine.


• Anesthetics, hydrocarbon inhalation - Concurrent use of chloroform, cyclopropane, halothane, or trichloroethylene with pseudoephedrine may increase the risk of severe ventricular arrhythmias because these anesthetics greatly sensitize the myocardium to the effects of sympathomimetic amines; pseudoephedrine should be used with caution and in substantially reduced dosage in patients receiving these anesthetics. Enflurane, isoflurane, or methoxyflurane may also cause some sensitization of the myocardium to the effects of sympathomimetic amines.


• Anesthetics, parenteral-local - Pseudoephedrine should be used cautiously and in carefully circumscribed quantities, if at all, with local anesthetics for anesthetizing areas with end arteries (such as the finger, toes, or penis) or otherwise compromised blood supply; ischemia leading to gangrene may result.


• Anticholinergics - Concurrent use with anticholinergic effects; patients should be advised to report occurrence of gastrointestinal problems promptly since paralytic ileus may occur with concurrent therapy.


• Antidepressants, trycyclic or maprotiline - Concurrent use may potentiate the cardiovascular effects of pseudoephedrine, possible resulting in arrhythmias, tachycardia, or severe hypertension or hyperpyrexia.


• Antihypertensives, or diuretics used as - Antihypertensive effects may be reduced when these medications are used concurrently with pseudoephedrine; the patient should be carefully monitored to confirm that the desired effect is being obtained.


• β-adrenergic blocking agents - Therapeutic effects may be inhibited when these medications are used concurrently with pseudoephedrine, especially larger doses; also, β-adrenergic blockage may result in unopposed α-adrenergic activity with a risk of hypertension and excessive bradycardia with possible heart chlorpheniramine, resulting in headache, cardiac arrhythmias, vomiting or sudden and severe hypertensive and/or hyperpyretic crisis. These medications should not be administered during or within 14 days following the administration of MAO inhibitor therapy.  


• Metoclopramide - Concurrent use of metoclopramide with anticholinergics may antagonize metoclopramide's effects on gastrointestinal motility.


• Potassium chloride - Concurrent use with anticholinergics may increase the severity of potassium chloride-induced gastrointestinal lesions.


• Rauwolfia alkaloids - Concurrent use may prolong the direct-acting sympathomimetic amines by preventing the uptake into storage granules.
  

Laboratory Test Interactions:

Antihistamines may interfere with diagnostic test results for skin tests using allergen extracts.

Anticholinergics may interfere with diagnostic test results for gastric acid secretion by antagonizing the

effect of pantagastrin and histamine, and for radionucleotide gastric emptying studies by delaying gastric

emptying.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

No data is available on the long-term potential of the components of this product for Carcinogenesis,

Mutagenesis or Impairment of Fertility in animals or humans.

Pregnancy: Category C:

Reproduction studies have been performed with chlorpheniramine maleate. Studies in rabbits and rats at doses

up to 50 times and 85 times the human dose revealed no evidence of harm to the fetus. There are, however, no

adequate and well-controlled studies in pregnant women. Therefore, it is not known whether these drugs can

cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.


Animal reproduction studies have not been conducted with pseudoephedrine or methscopolamine. This product

should be given to a pregnant woman only if clearly needed.

Labor and Delivery:

Use of pseudoephedrine during labor may cause fetal anoxia and bradycardia by increasing contractility of the

uterus and decreasing uterine blood flow.

Nursing Mothers:

Small amounts of sympathomimetic amines and antihistamines are excreted in breast milk; use is not

recommended because of the risk of adverse effects, such as unusual excitement or irritability in infants.

Anticholinergics and antihistamines may inhibit lactation.

Pediatric Use:

Use of antihistamines is not recommended in newborn or premature infants because this age group has

an increased susceptibility to anticholinergic side effects, such as CNS excitation, and an increased

tendency toward convulsion. In infants and children, overdosage may cause hallucinations, convulsions,

and death. A paradoxical reaction characterized by hyperexcitability may occur in older children taking

antihistamines.


Use is not recommended for children under six years of age. Infants and young children with spastic

paralysis or brain damage since an increased response to anticholinergics are given to children where the

environmental temperature because of the suppression of sweat gland activity. A paradoxical reaction

characterized by hyperexcitability may occur in children taking large doses of anticholinergics.


Appropriate studies with pseudoephedrine have not been performed in the pediatric population.

Geriatric Use:

Confusion, hallucinations, seizures, and CNS depression may be more likely to occur in geriatric patients

taking sympathomimetic amines. Geriatric patients may also be more sensitive to the effects, especially

the vasopressor effects, of sympathomimetic amines. Confusion, dizziness, sedation, hypotension,

hyperexcitability, and anticholinergic side effects, such as dryness of mouth and urinary retention

(especially in males), may be more likely to occur in geriatric patients taking antihistamines.


Geriatric patients may respond to usual doses of anticholinergics with excitement, agitation, drowsiness,

or confusion. Geriatric patients are especially susceptible to the anticholinergic side effects, such as

constipation, dryness of the mouth, and urinary retention (especially in males). If these side effects occur

and continue or are severe, medication should probably be discontinued.


Caution is also recommended when anticholinergics are given to geriatric patients, because of the danger

of precipitating undiagnosed glaucoma. Memory may become severely impaired in geriatric patients, with

the continued use of anticholinergics, since these drugs block the action of acetylcholine, which is

responsible for many functions of the brain, including memory function.

ADVERSE REACTIONS:

The following adverse reactions have been observed with the use of pseudoephedrine, chlorpheniramine

and methscopolamine; Arrhythmias, blood dyscrasias, CNS depression, CNS stimulation, dizziness,

drowsiness, dryness of mouth, hallucinations, hypotension, hypertension, increased sweating, loss of

appetite, paradoxical reaction, restlessness, skin rash, stomach upset or pain, thickening of mucus,

tingling in hands or feet, trembling, troubled breathing, unusual tiredness or weakness, vomiting.


Note: Agitation; confusion; difficult or painful urination; drowsiness; dizziness; and dryness of mouth, nose

and throat are more likely to occur in the elderly. Nightmares, unusual excitement, nervousness, restlessness,

or irritability are more likely to occur in children and the elderly. When anticholinergics are given to patients,

especially children, where the environmental temperature is high, there is risk of a rapid increase in body

temperature.

Drug Abuse and Dependence

Central nervous system stimulants such as pseudoephedrine have been abused. At high doses, subjects

commonly experience an elevation of mood, a sense of increased energy and alertness, and decreased

appetite. Some individuals become anxious, irritable and loquacious. In addition to the marked euphoria, the

user experiences a sense of markedly enhanced physical strength and mental capacity. With continued use,

tolerance develops, the user increases the dose, and toxic signs and symptoms appear. Depression may

follow rapid withdrawal.

Stimulants, such as pseudoephedrine, are banned and tested for by the U.S. Olympic Committee (USOC) and

the National Collegiate Athletic Association (NCAA).

Overdosage

This product is comprised of pharmacologically different components (sympathomimetic amine, antihistamine,

anticholinergic). Therefore, it is difficult to predict the exact manifestation of symptoms in a given individual.

Reaction to an overdose of this product may vary from CNS depression to stimulant. A description of symptoms

which are likely to appear after ingestion of an excess of the individual components follows:

• Overdosage with sympathomimetic amines can cause cardiac arrhythmias, cerebral hemorrhage and pulmonary edema. It can also cause palpitations, tremor, dizziness, vomiting, fear, labored breathing, headache, dryness of mouth, pallor, weakness, panic, anxiety, confusion, and hallucinations.


• Manifestation of antihistamine overdosage may vary from CNS depression to stimulation. Other signs and symptoms may be dizziness, tinnitus, ataxia, blurred vision, and hypotension. Stimulation is particularly likely in children as are atropine-like signs and symptoms (dry mouth, fixed, dilated pupils, flushing, hypothermia, and gastrointestinal symptoms). In infants and children particularly, antihistamines, in overdosage may produce convulsion and/or death.


• The signs and symptoms of overdosage of anticholinergics are headache, nausea, vomiting, blurred vision, fixed and dilated pupils, hot dry skin, dizziness, dryness of mouth, difficulty in swallowing and CNS stimulation.

Treatment of acute overdosage would probably be based upon treating the patient for pseudoephedrine toxicity

which may manifest itself as excessive CNS stimulation resulting in excitement, tremor, restlessness, and

insomnia. Other effects may inculde hyperpyrexia, hypertension, mydriasis, hyperglycemia and urinary retention.

Severe hyperkalemia can occur, probably due to a compartmental shift. No organ damage or significant metabolic

derangement is associated with overdosage.


General Treatment: Treatment is symptomatic and supportive with possible utilization of the following:

• Induction of emesis (syrup of Ipecac recommended); however, precaution against aspiration is necessary, especially in infants and children.


• Gastric lavage (isotonic or 0.45% sodium chloride solution) if patient is unable to vomit within three hours of ingestion.


• Saline Cathartics (milk of magnesia) may be used.


• Vasopressors to treat hypotension; however epinephrine should not be used since it may further lower blood pressure.


• For excessive hypertensive effect an α-adrenergic blocker, such as phentolamine, may be administered.


• Hyperpyrexia, especially in children, may require treatment with tepid water sponge bath.


• Excessive CNS stimulation may be counteracted with parenteral diazepam.


• Oxygen and intravenous fluids.


• Precaution against the use of stimulants (analeptic agents) is recommended because they may cause seizures.


• Excitement to a degree which demands attention may be managed with sodium thiopental 2% solution given slowly intravenously or chloral hydrate (100-200 mL of a 2% solution) by rectal infusion.

In severe cases of overdosage it is essential to monitor both the heart (by electrocardiograph) and plasma electrolytes,

and to give intravenous potassium as indicated. In the event of progression of the respiration should be instituted and

maintained until effective respiratory action returns.

DOSAGE AND ADMINISTRATION:

Adults and children 12 years of age and older: 1-2 teaspoonfuls (5-10 mL) every 4 to 6 hours, not to

exceed 8 teaspoonfuls in 24 hours.


Children 6 to under 12 years of age: 1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed 4 teaspoonfuls

in 24 hours.


DryMax Syrup is not recommended for children under 6 years of age.


Note: Geriatric patients may be more sensitive to the effects of the usual adult dose. Adjust adult dose

accordingly.

HOW SUPPLIED:

DryMax Syrup is supplied as a purple, grape flavored, alcohol free, gluten free. in 4 fl oz (118 mL)

bottles, NDC 64661-090-04.


KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. IN CASE

OF ACCIDENTAL OVERDOSE, CALL A DOCTOR OR CONTACT A POISON CONTROL

CENTER IMMEDIATELY.


Pharmacist: Store at controlled room temperature, 15o-30oC (59o-86oF).

Avoid exposure to heat.


Supplied in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.


Manufactured for:

JayMac Pharmaceuticals

Sunset, LA 70584


Manufactured by:

Great Southern Laboratories

Houston, TX 77099


I - 192                   Rev. 12/09

PRODUCT PACKAGING:

The packaging below represents the labeling currently used:


Principal Display Panel and Side Panel for 118mL Label:


NDC 64661-090-04


DryMax

Syrup


Each teaspoonful (5 mL) contains:

Chlorpheniramine Maleate........... 4 mg

Methscopolamine Nitrate........ 1.25 mg

Pseudoephedrine HCl................ 30 mg


ANTIHISTAMINE / ANTICHOLINERGIC

NASAL DECONGESTANT


ALCOHOL FREE / GLUTEN FREE


Rx Only


4 fl oz (118 mL)



Side Panel:


DOSAGE AND ADMINISTRATION:

Adults and children 12 years of age and older:

1-2 teaspoonfuls (5-10 mL) every 4 to 6 hours, not to exceed 8 teaspoonfuls in 24 hours.

Children 6 to under 12 years of age: 1 teaspoonful (5 mL) every 4 to 6 hours, not to

exceed 4 teaspoonfuls in 24 hours.

DryMax Syrup is not recommended for children under 6 years of age.


STORAGE: Store at controlled room temperature, 15o-30oC (59o-86oF). Avoid exposure to heat.


Supplied in a tight, light-resistant container with a child-resistant cap.


Tamper evident by foil seal under cap. Do not use if foil seal is broken or missing.


KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. IN CASE

OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT

A POISON CONTROL CENTER IMMEDIATELY.


Manufactured by:

Great Southern Laboratories

Houston, TX 77099


Manufactured for:

JayMac Pharmaceuticals

Sunset, LA 70584


Rev. 12/09

DRYMAX  chlorpheniramine maleate, methscopolamine nitrate, pseudoephedrine hydrochloride  syrup

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 64661-090 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Chlorpheniramine Maleate (Chlorpheniramine) Chlorpheniramine Maleate 4 mg  in 5 mL Methscopolamine Nitrate (Methscopolamine) Methscopolamine Nitrate 1.25 mg  in 5 mL Pseudoephedrine Hydrochloride (Pseudoephedrine) Pseudoephedrine Hydrochloride 30 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor GRAPE Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 64661-090-04 118 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		01/18/2010

Labeler - JayMac Pharmaceuticals LLC (830767260)

Registrant - Great Southern Laboratories (056139553)

Establishment
Name	Address	ID/FEI	Operations
Great Southern Laboratories		056139553	manufacture

Revised: 01/2010JayMac Pharmaceuticals LLC

More DryMax Syrup resources

• DryMax Syrup Side Effects (in more detail)
• DryMax Syrup Dosage
• DryMax Syrup Use in Pregnancy & Breastfeeding
• DryMax Syrup Drug Interactions
• DryMax Syrup Support Group
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