Pronunciation: a-MOX-i-SIL-in/kla-RITH-roe-MYE-sin/lan-SOE-pra-zole
Generic Name: Amoxicillin/Clarithromycin/Lansoprazole
Brand Name: Prevpac
Prevpac Therapy Pack is used for:
Treating certain patients who have Helicobacter pylori infection and duodenal ulcer.
Prevpac Therapy Pack is a proton pump inhibitor (PPI), penicillin antibiotic, and macrolide antibiotic combination. It works by killing H. pylori bacteria and reducing stomach acid. This helps to heal the ulcer and prevent it from coming back.
Do NOT use Prevpac Therapy Pack if:
- you are allergic to any ingredient in Prevpac Therapy Pack, to any penicillin antibiotic (eg, ampicillin), or to any macrolide antibiotic (eg, erythromycin)
- you have severe kidney problems or infectious mononucleosis (mono)
- you have had liver problems or yellowing of the skin or eyes caused by previous use of clarithromycin
- you are taking alfuzosin, astemizole, atazanavir, cabazitaxel, cisapride, conivaptan, diltiazem, docetaxel, dofetilide, dronedarone, eletriptan, an ergot alkaloid (eg, dihydroergotamine, ergotamine), lovastatin, lurasidone, nilotinib, pimozide, propafenone, quinupristin/dalfopristin, ranolazine, romidepsin, salmeterol, silodosin, simvastatin, tamsulosin, terfenadine, tetrabenazine, ticagrelor, tolvaptan, or toremifene
- you have kidney or liver problems and you are also taking colchicine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Prevpac Therapy Pack:
Some medical conditions may interact with Prevpac Therapy Pack. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood potassium or magnesium levels, liver or kidney problems, blood problems (eg, porphyria), or myasthenia gravis
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with Prevpac Therapy Pack. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Many prescription and nonprescription medicines (eg, used for allergies, anxiety, asthma or other breathing problems, blood thinning, cancer, decreased blood clot formation, diabetes, enlarged prostate, erectile dysfunction, gout, heart problems, high blood pressure, high cholesterol, high prolactin levels, HIV, immune system suppression, infections, inflammation, irregular heartbeat, malaria, mental or mood problems, migraines, nausea and vomiting, pain, parathyroid problems, pulmonary arterial hypertension [PAH], overactive bladder, seizures, sleep, stomach or bowel problems, Tourette syndrome, and other conditions), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Prevpac Therapy Pack, increasing the risk of side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if Prevpac Therapy Pack may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Prevpac Therapy Pack:
Use Prevpac Therapy Pack as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Prevpac Therapy Pack by mouth before a meal in the morning and in the evening unless your doctor tells you differently.
- Swallow Prevpac Therapy Pack whole. Do not break, crush, or chew before swallowing.
- If you also take sucralfate, do not take it within 30 minutes after taking Prevpac Therapy Pack. Check with your doctor if you have questions.
- If you are also taking zidovudine, do not take it within 2 hours before or after you take the clarithromycin.
- To clear up your infection completely, take Prevpac Therapy Pack for the full course of treatment. Keep taking it even if you feel better in a few days.
- Continue to take Prevpac Therapy Pack even if you feel well. Do not miss any doses.
- If you miss a dose of Prevpac Therapy Pack, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about the proper use of Prevpac Therapy Pack.
Important safety information:
- Prevpac Therapy Pack may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Prevpac Therapy Pack with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Prevpac Therapy Pack only works against bacteria; it does not treat viral infections (eg, the common cold).
- Lansoprazole, an ingredient in Prevpac Therapy Pack, may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use Prevpac Therapy Pack in high doses, for long periods of time, or if you are over 50 years old. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Contact your doctor if you have any questions about this information.
- Prevpac Therapy Pack contains a PPI. Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking Prevpac Therapy Pack for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use Prevpac Therapy Pack.
- Be sure to use Prevpac Therapy Pack for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of Prevpac Therapy Pack may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Severe and sometimes fatal liver problems have been reported with clarithromycin. This has usually been reversible when the medicine is stopped. Discuss any questions or concerns with your doctor. Tell your doctor right away if you experience symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness).
- Tell your doctor or dentist that you take Prevpac Therapy Pack before you receive any medical or dental care, emergency care, or surgery.
- Diabetes patients - Prevpac Therapy Pack may rarely affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- There have been reports of tooth discoloration with the use of clarithromycin. This has usually been reversible with a dental cleaning.
- There have been reports of hearing loss with use of clarithromycin, usually in elderly women. This has usually been reversible. Discuss any questions or concerns with your doctor.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Prevpac Therapy Pack. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Talk with your doctor before you receive any live vaccine (eg, typhoid) while you are taking Prevpac Therapy Pack.
- Prevpac Therapy Pack may interfere with certain lab tests, including certain urine glucose tests. Be sure your doctor and lab personnel know you are taking Prevpac Therapy Pack.
- Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Prevpac Therapy Pack. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Prevpac Therapy Pack should be used with caution in Asian patients; the risk of side effects may be increased in these patients.
- Use Prevpac Therapy Pack with caution in the ELDERLY; they may be more sensitive to its effects, especially liver problems; kidney problems; and hip, wrist, and spine fractures.
- Prevpac Therapy Pack should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Clarithromycin has been shown to cause harm to the fetus. It is not recommended for use during pregnancy except when no other antibiotics can be used. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prevpac Therapy Pack while you are pregnant. Prevpac Therapy Pack is found in breast milk. Do not breast-feed while taking Prevpac Therapy Pack.
Possible side effects of Prevpac Therapy Pack:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Changes in taste; diarrhea; dizziness; dry mouth; headache; indigestion; nausea; stomach discomfort.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; bone pain; confusion; decreased urination; fast or irregular heartbeat; hallucinations; loss of taste or sense of smell; mental or mood changes (eg, depression); muscle weakness; nightmares; pain, swelling, sores, or white patches in the mouth; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe stomach pain or cramps; severe or persistent dizziness; symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness); tremor; trouble sleeping; vaginal discharge, pain, or itching.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Prevpac side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; nausea; stomach pain; vomiting.
Proper storage of Prevpac Therapy Pack:
Store Prevpac Therapy Pack at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Prevpac Therapy Pack out of the reach of children and away from pets.
General information:
- If you have any questions about Prevpac Therapy Pack, please talk with your doctor, pharmacist, or other health care provider.
- Prevpac Therapy Pack is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Prevpac Therapy Pack. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Prevpac resources
- Prevpac Side Effects (in more detail)
- Prevpac Use in Pregnancy & Breastfeeding
- Prevpac Drug Interactions
- Prevpac Support Group
- 9 Reviews for Prevpac - Add your own review/rating
Compare Prevpac with other medications
- Helicobacter Pylori Infection
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